Autore: Pastoris, O. Dossena, M. Fulle, D. Taglietti, M. Bernardi, R. Benzi, G.
ID: 415
(Experimental evaluation of the effect of biological substances on some biochemical parameters relat
Parole ChiaveE' stato studiato nel muscolo gastrocnemio di ratto adulto normale, l'effetto della somminstrazione i.p. di uridin-5'-difosfoglucosio (UDGP) sia su subtrati ed intermedi della glicolisi e del ciclo di Krebs, sia sugli aminoacidi correlati, ione ammonio, sia sui depositi e sui mediatori di energia e sulla carica energetica potenziale. L'UDGP è stato somministrato alle dosi di 0.8; 2,0; 5,0 mg-kg i.p. per 1,2, e 4 settimane. Si è valutato l'effetto dei fattori
KeywordsThe effect of intraperitoneal administration of uridine-diphosphate glucose (UDGP) were studied on male rat gastrocnemius muscle. Muscular glycolitic substrates and metabolites (glycogen, glucose, glucose-6-phosphate, pyruvate, lactate), Krebs' cycle intermediates (citrate, alfa-ketoglutarate, malate), related amino acids (glutamate, alanine), ammonia, energy store and mediators (creatine phosphate, ATP, ADP, AMP) and the energy charge potential were evaluated. UDGP was intraperitoneally admnistered at the doses of 0,8, 2,0 and 5,0 mg-kg daily for periods of 1,2, and 4 weeks. The influence of the factors \"dose of UDGP and \"time course\" of treatment was defined. The administration of the three doses tested of UDGP on male rat gastrocenmius muscle produced changes on some glycolitic metabolites and especially on some Krebs' cycle intermediates. These effects were particularly evident after two weeks of treatment with UDGP.